Belgium Gholamreza Hassanzadeh-Ghassabeh Vlaams Instituut voor Biotechnologie.To perform effective antibody validation.Select the most appropriate antibodies that are available either their laboratory or on the market.The paper provides the essential fundamental principles to enable researchers: The EuroMAbNet network also benefits from including three small-specialised companies ( SCICONS, Sanovo Biotech, Vertebrate Antibodies) that promote strong links between academia and industry.ĮuroMAbNet has published a position paper containing guidelines on antibody validation and use to help find reagents that are 'fit for purpose'. T and B immunotherapies for use in cancer, graft versus host disease. Development and production of potential immunotherapeutic agents e.g.proteome and dsRNAome analysis, virology, and antibody panels in routine clinical laboratories. Use of monoclonal and polyclonal antibodies as research/diagnostic/ prognostic tools e.g.Use of bioinformatics, epitope mapping and iRNA to validate and characterize antibodies.immunohistochemistry, flow cytometric and biochemical techniques. Complete validation and characterization of antibodies e.g.hybridoma, phage display, nanobody and recombinant technology. Antibody production using a wide variety of techniques e.g.Production of antibodies in a wide variety of animal species e.g.short peptides, recombinant proteins, small molecule, viral antigens. Identification and production of immunogens e.g.Formed in 2008 and now spanning eleven European countries, EuroMAbNet members possess a wealth of expertise in antibody technology.
The European Monoclonal Antibodies Network (EuroMAbNet) represents the first European network of laboratories linked to academic institutions each with an internationally recognized reputation in the production and use of validated antibodies.
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